Skip to main content
5 Unexpected Symptoms of Syphilis You Need to Know About
February 17, 2025 at 10:00 PM
A healthcare professional wearing scrubs and eyeglasses using a laptop with a stethoscope around the neck.


When we think about syphilis, many of us might picture the classic symptom: a sore, called a chancre, that appears at the site of infection, often on or around the genitals. While this is certainly one of the most common signs, syphilis is a lot more complicated than just one symptom. In fact, syphilis can present itself in ways that might surprise you, and it’s important to be aware of all its potential manifestations. The earlier you spot the symptoms, the easier it is to treat and prevent long-term damage.

Here’s a rundown of five unexpected symptoms of syphilis that you might not expect. If you think you’ve been exposed or notice any of these, it’s time to seek online syphilis treatment.

1. Rashes That Appear Anywhere on Your Body

One of the most unexpected symptoms of syphilis is a rash, which can show up in places you may not anticipate. While most people associate rashes with the genital region in cases of STDs, syphilis doesn’t always follow the rules. In its secondary stage, syphilis can cause a red, brownish, or even slightly yellowish rash to develop—often on your palms and the soles of your feet. These rashes can be rough, and while they aren’t usually painful or itchy, they’re highly indicative of the infection.

The rash may appear in places where you wouldn’t immediately think to check, and because it’s not always obvious or painful, it can easily be mistaken for something else, like a mild allergic reaction or a skin irritation. However, if you notice an unusual rash that doesn’t go away, especially if you’ve had unprotected sex, you should get tested for syphilis as soon as possible.

2. Painless Ulcers or Sores (Not Just Down Below)

Syphilis is famous for its first symptom: a small, round, painless sore called a chancre. This sore often appears on or around the genital area but can show up in other unexpected places too. These sores can also develop on your lips, mouth, or even your anus. If you have a chancre in a spot that's not readily visible—like on your lips or in your mouth—you might not even realize you have syphilis.

These sores are painless, which means many people don’t notice them until they’re discovered during a physical exam or until other symptoms develop. What’s tricky is that syphilis can still be contagious at this stage, even if there are no painful sores present. If you notice a sore anywhere on your body that won’t go away, especially if it appears near an area where you’ve had sexual contact, you need to seek medical attention.

3. Swollen Lymph Nodes

Lymph nodes are part of your immune system, and they help fight off infections. When your body is dealing with an infection, these nodes—especially in areas like your neck, groin, and armpits—can swell up as they work overtime to combat the invader. Swollen lymph nodes are common in people with syphilis, particularly during the secondary stage.

You may notice that your lymph nodes feel tender or swollen when you press on them, or you might simply feel a lump or bump in your neck, groin, or armpit. While swollen lymph nodes can occur for a variety of reasons, it’s a good idea to take note of them, especially if you have other symptoms like a rash or sore. They are often an early warning sign that your body is fighting syphilis, and a good indicator that you should schedule an appointment for testing.

4. Flu-like Symptoms That Won’t Quit

Syphilis can be sneaky, and its flu-like symptoms are one of the ways it disguises itself. Many people with syphilis experience symptoms that mimic a cold or the flu. This can include:

  • Headaches
  • Fever
  • Sore throat
  • Fatigue
  • Muscle aches

It can be easy to mistake these symptoms for a common cold or the flu, but there’s one important difference: Syphilis doesn’t go away on its own like a cold or flu might. If you’ve been feeling rundown with no clear reason, or if you have these symptoms without an obvious cold or virus, it’s essential to get checked out for syphilis, particularly if you’ve had any unprotected sexual encounters.

5. Hair Loss or Patches of Baldness

Now, this is a symptom that’s not widely discussed. But believe it or not, syphilis can cause hair loss during its secondary stage. Known as "moth-eaten" hair loss, this condition leads to bald patches that look as though they’ve been eaten away, leaving small, round patches of thinning or missing hair.

The hair loss is often gradual and can affect both men and women. It can be especially alarming because hair loss is typically associated with other conditions, like stress or hormonal imbalances. However, if you’re experiencing hair loss along with other symptoms like rashes, flu-like symptoms, or swollen lymph nodes, it could be a sign of syphilis, and it’s important to see a healthcare provider.

Ready to Take Action?

If you’ve noticed any of these unexpected symptoms, don’t wait for things to get worse. At GoodMds, we’re here to help you get the online syphilis treatment you need—quickly, discreetly, and conveniently. Whether it’s syphilis, chlamydia, gonorrhea, or any other STD, we’ve got your back. We provide online consultations and prescriptions, allowing you to get the care you deserve without leaving your home.

Book an online consultation with one of our experienced healthcare providers today, and start feeling like yourself again. Stay safe, stay healthy, and get the online syphilis treatment you need—whenever you need it.

Subscribe to our newsletter
Let's keep in touch!

Stay updated on our news and events! Sign up to receive our newsletter.